Transferable Domain in the G(1) Cyclin Cln2 Sufficient To Switch Degradation of Sic1 from the E3 Ubiquitin Ligase SCF(Cdc4) to SCF(Grr1)

Degradation of Saccharomyces cerevisiae G(1) cyclins Cln1 and Cln2 is mediated by the ubiquitin-proteasome pathway and involves the SCF E3 ubiquitin-ligase complex containing the F-box protein Grr1 (SCF(Grr1)). Here we identify the domain of Cln2 that confers instability and describe the signals in...

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Bibliographic Details
Main Authors: Berset, Catherine, Griac, Peter, Tempel, Rebecca, La Rue, Janna, Wittenberg, Curt, Lanker, Stefan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC133886/
https://ncbi.nlm.nih.gov/pubmed/12052857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.13.4463-4476.2002
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