Constitutive Association of BRCA1 and c-Abl and Its ATM-Dependent Disruption after Irradiation

BRCA1 plays an important role in mechanisms of response to double-strand breaks, participating in genome surveillance, DNA repair, and cell cycle checkpoint arrests. Here, we identify a constitutive BRCA1-c-Abl complex and provide evidence for a direct interaction between the PXXP motif in the C ter...

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Detalhes bibliográficos
Main Authors: Foray, Nicolas, Marot, Didier, Randrianarison, Voahangy, Dalla Venezia, Nicole, Picard, Didier, Perricaudet, Michel, Favaudon, Vincent, Jeggo, Penny
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133860/
https://ncbi.nlm.nih.gov/pubmed/12024016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.12.4020-4032.2002
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