Mutational Analysis of All Conserved Basic Amino Acids in RAG-1 Reveals Catalytic, Step Arrest, and Joining-Deficient Mutants in the V(D)J Recombinase

Although both RAG-1 and RAG-2 are required for all steps of V(D)J recombination, little is known about the specific contribution of either protein to these steps. RAG-1 contains three acidic active-site amino acids that are thought to coordinate catalytic metal ions. To search for additional catalyt...

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Detalles Bibliográficos

Publicado en:	Mol Cell Biol
Autores principales:	Huye, Leslie E., Purugganan, Mary M., Jiang, Ming-Ming, Roth, David B.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 2002
Materias:	DNA Dynamics and Chromosome Structure
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133788/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11971977/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.10.3460-3473.2002
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