Regulation of Jak2 through the Ubiquitin-Proteasome Pathway Involves Phosphorylation of Jak2 on Y1007 and Interaction with SOCS-1

The family of cytoplasmic Janus (Jak) tyrosine kinases plays an essential role in cytokine signal transduction, regulating cell survival and gene expression. Ligand-induced receptor dimerization results in phosphorylation of Jak2 on activation loop tyrosine Y1007 and stimulation of its catalytic act...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Ungureanu, Daniela, Saharinen, Pipsa, Junttila, Ilkka, Hilton, Douglas J., Silvennoinen, Olli
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2002
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133778/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11971965/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.10.3316-3326.2002
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