Calpain-Mediated Bid Cleavage and Calpain-Independent Bak Modulation: Two Separate Pathways in Cisplatin-Induced Apoptosis

Calpain is a ubiquitous protease with potential involvement in apoptosis. We report that in human melanoma cells, cisplatin-induced calpain activation occurs early in apoptosis. Calpain activation and subsequent apoptosis were inhibited by calpeptin and PD150606, two calpain inhibitors with differen...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Mandic, Aleksandra, Viktorsson, Kristina, Strandberg, Linda, Heiden, Thomas, Hansson, Johan, Linder, Stig, Shoshan, Maria C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2002
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133754/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11940658/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.22.9.3003-3013.2002
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