Calpain-Mediated Bid Cleavage and Calpain-Independent Bak Modulation: Two Separate Pathways in Cisplatin-Induced Apoptosis

Calpain is a ubiquitous protease with potential involvement in apoptosis. We report that in human melanoma cells, cisplatin-induced calpain activation occurs early in apoptosis. Calpain activation and subsequent apoptosis were inhibited by calpeptin and PD150606, two calpain inhibitors with differen...

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Bibliografiske detaljer
Main Authors: Mandic, Aleksandra, Viktorsson, Kristina, Strandberg, Linda, Heiden, Thomas, Hansson, Johan, Linder, Stig, Shoshan, Maria C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2002
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC133754/
https://ncbi.nlm.nih.gov/pubmed/11940658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.9.3003-3013.2002
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