The Direct Recruitment of BLNK to Immunoglobulin α Couples the B-Cell Antigen Receptor to Distal Signaling Pathways

Following B-cell antigen receptor (BCR) ligation, the cytoplasmic domains of immunoglobulin α (Igα) and Igβ recruit Syk to initiate signaling cascades. The coupling of Syk to several distal substrates requires linker protein BLNK. However, the mechanism by which BLNK is recruited to the BCR is unkno...

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Detalhes bibliográficos
Main Authors: Kabak, Shara, Skaggs, Brian J., Gold, Michael R., Affolter, Michael, West, Kelly L., Foster, Mark S., Siemasko, Karyn, Chan, Andrew C., Aebersold, Ruedi, Clark, Marcus R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133735/
https://ncbi.nlm.nih.gov/pubmed/11909947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2524-2535.2002
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