Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

p73 is a p53-related tumor suppressor but is also induced by oncogene products such as E2F-1, raising a question as to whether p73 is a tumor suppressor gene or oncogene. Unlike p53, p73 has several variants, including ΔNp73, which lacks the NH(2)-terminal transactivation domain. Although, in develo...

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Autores principales: Nakagawa, Takahito, Takahashi, Masato, Ozaki, Toshinori, Watanabe, Ken-ichi, Todo, Satoru, Mizuguchi, Hiroyuki, Hayakawa, Takao, Nakagawara, Akira
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC133713/
https://ncbi.nlm.nih.gov/pubmed/11909952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.8.2575-2585.2002
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