ErbB2/Neu-Induced, Cyclin D1-Dependent Transformation Is Accelerated in p27-Haploinsufficient Mammary Epithelial Cells but Impaired in p27-Null Cells

ErbB2/Neu destabilizes the cyclin-dependent kinase (Cdk) inhibitor p27 and increases expression of cyclin D1. Therefore, we studied the roles of p27 and cyclin D1 in ErbB2-mediated mammary epithelial cell transformation. Overexpression of ErbB2 or cyclin D1 in p27(+/−) primary murine mammary epithel...

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Detalhes bibliográficos
Main Authors: Muraoka, Rebecca S., Lenferink, Anne E. G., Law, Brian, Hamilton, Elizabeth, Brantley, Dana M., Roebuck, L. Renee, Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133673/
https://ncbi.nlm.nih.gov/pubmed/11884607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.7.2204-2219.2002
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