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Gradient of E2A Activity in B-Cell Development
The E2A locus is a frequent target of chromosomal translocations in B-cell acute lymphoblastic leukemia (B-ALL). E2A encodes two products, E12 and E47, that are part of the basic helix-loop-helix (bHLH) family of transcription factors and are central in B lineage differentiation. E2A haplo-insuffici...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133542/ https://ncbi.nlm.nih.gov/pubmed/11784864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.3.886-900.2002 |
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