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Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding

Although structures of single-stranded (ss)DNA-binding proteins (SSBs) have been reported with and without ssDNA, the mechanism of ssDNA binding in eukarya remains speculative. Here we report a 2.5 Å structure of the ssDNA-binding domain of human replication protein A (RPA) (eukaryotic SSB), for whi...

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Udgivet i:EMBO J
Principais autores: Bochkareva, Elena, Belegu, Visar, Korolev, Sergey, Bochkarev, Alexey
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC133470/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11157767/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.3.612
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