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A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

The number of red blood cells is normally tightly regulated by a classic homeostatic mechanism based on oxygen sensing in the kidney. Decreased oxygen delivery resulting from anemia induces the production of erythropoietin, which increases red cell production and hence oxygen delivery. Investigation...

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Detalhes bibliográficos
Main Authors: Percy, Melanie J., Zhao, Quan, Flores, Adrian, Harrison, Claire, Lappin, Terence R. J., Maxwell, Patrick H., McMullin, Mary Frances, Lee, Frank S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1334658/
https://ncbi.nlm.nih.gov/pubmed/16407130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508423103
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