Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study

BACKGROUND: The early to intermediate stages of the majority of colorectal tumours are thought to be driven by aberrations in the Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A smaller proportion of cancers shows mismatch repair deficiency. The aim of this study was to analyse the co-occurrence of th...

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Autors principals: Lüchtenborg, Margreet, Weijenberg, Matty P, Wark, Petra A, Saritas, A Merdan, Roemen, Guido MJM, van Muijen, Goos NP, de Bruïne, Adriaan P, van den Brandt, Piet A, de Goeij, Anton FPM
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2005
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1334229/
https://ncbi.nlm.nih.gov/pubmed/16356174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-5-160
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