Selective generation of functional somatically mutated IgM(+)CD27(+), but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease

Individuals with X-linked lymphoproliferative disease (XLP) display defects in B cell differentiation in vivo. Specifically, XLP patients do not generate a normal number of CD27(+) memory B cells, and those few that are present are IgM(+). Recent studies have suggested that IgM(+)CD27(+) B cells are...

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Détails bibliographiques
Auteurs principaux: Ma, Cindy S., Pittaluga, Stefania, Avery, Danielle T., Hare, Nathan J., Maric, Irina, Klion, Amy D., Nichols, Kim E., Tangye, Stuart G.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2006
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1332028/
https://ncbi.nlm.nih.gov/pubmed/16424938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25720
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