Characterization of Two Novel Pyrogenic Toxin Superantigens Made by an Acute Rheumatic Fever Clone of Streptococcus pyogenes Associated with Multiple Disease Outbreaks

The pathogenesis of acute rheumatic fever (ARF) is poorly understood. We identified two contiguous bacteriophage genes, designated speL and speM, encoding novel inferred superantigens in the genome sequence of an ARF strain of serotype M18 group A streptococcus (GAS). speL and speM were located at t...

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Detalhes bibliográficos
Main Authors: Smoot, Laura M., McCormick, John K., Smoot, James C., Hoe, Nancy P., Strickland, Ian, Cole, Robert L., Barbian, Kent D., Earhart, Cathleen A., Ohlendorf, Douglas H., Veasy, L. George, Hill, Harry R., Leung, Donald Y. M., Schlievert, Patrick M., Musser, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Bacterial Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC133074/
https://ncbi.nlm.nih.gov/pubmed/12438391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.7095-7104.2002
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