The Bacterial Redox Protein Azurin Induces Apoptosis in J774 Macrophages through Complex Formation and Stabilization of the Tumor Suppressor Protein p53

Two redox proteins, azurin and cytochrome c(551) elaborated by Pseudomonas aeruginosa, demonstrate significant cytotoxic activity towards macrophages. Azurin can enter macrophages, localize in the cytosol and nuclear fractions, and induce apoptosis. Two redox-negative mutants of azurin have less cyt...

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Bibliographische Detailangaben
Hauptverfasser: Yamada, Tohru, Goto, Masatoshi, Punj, Vasu, Zaborina, Olga, Kimbara, Kazuhide, Das Gupta, T. K., Chakrabarty, A. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2002
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC133031/
https://ncbi.nlm.nih.gov/pubmed/12438386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.7054-7062.2002
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