Virulence Criteria for Brucella abortus Strains as Determined by Interferon Regulatory Factor 1-Deficient Mice

Interferon regulatory factor 1-deficient (IRF-1(−/−)) mice infected with virulent Brucella abortus 2308 at 5 × 10(5) CFU developed acute hepatitis similar to many natural hosts but, unlike natural hosts, IRF-1(−/−) mice were unable to resolve infection and died. In contrast, IRF-1(−/−) mice survived...

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Autors principals: Ko, Jinkyung, Gendron-Fitzpatrick, Annette, Ficht, Thomas A., Splitter, Gary A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Bacterial Infections
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC132959/
https://ncbi.nlm.nih.gov/pubmed/12438380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.12.7004-7012.2002
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