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Antibodies selected from combinatorial libraries block a tumor antigen that plays a key role in immunomodulation

We searched for cell-surface-associated proteins overexpressed on B cell chronic lymphocytic leukemia (CLL) to use as therapeutic antibody targets. Antibodies binding the immunosuppressive molecule CD200 were identified by cell panning of an antibody phage display library derived from rabbits immuni...

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Autors principals: McWhirter, John R., Kretz-Rommel, Anke, Saven, Alan, Maruyama, Toshiaki, Potter, Kathleen N., Mockridge, C. Ian, Ravey, E. Prenn, Qin, Fenghua, Bowdish, Katherine S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1327729/
https://ncbi.nlm.nih.gov/pubmed/16418292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510081103
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