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Effect of CpG methylation on RAG1/RAG2 reactivity: implications of direct and indirect mechanisms for controlling V(D)J cleavage

It has been suggested that DNA methylation/demethylation is involved in regulating V(D)J rearrangement. Although methylated DNA is thought to induce an inaccessible chromatin structure, it is unclear whether DNA methylation can directly control V(D)J recombination independently of chromatin structur...

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Détails bibliographiques
Auteurs principaux: Nakase, Hiroshi, Takahama, Yousuke, Akamatsu, Yoshiko
Format: Artigo
Langue:Inglês
Publié: 2003
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326344/
https://ncbi.nlm.nih.gov/pubmed/12897800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor904
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