Regulation of dendritic cell maturation and function by Bruton's tyrosine kinase via IL-10 and Stat3

Btk plays crucial roles in the differentiation and activation of B and myeloid cells. Despite drastic reductions of other Ig isotypes, paradoxically high IgE responses have been known in btk mutant mice. Here we show that btk(–/–) dendritic cells exhibit a more mature phenotype and a stronger in vit...

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Bibliographische Detailangaben
Hauptverfasser: Kawakami, Yuko, Inagaki, Naoki, Salek-Ardakani, Shahram, Kitaura, Jiro, Tanaka, Hiroyuki, Nagao, Koichi, Kawakami, Yu, Xiao, Wenbin, Nagai, Hiroichi, Croft, Michael, Kawakami, Toshiaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1325006/
https://ncbi.nlm.nih.gov/pubmed/16371463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509784103
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