CYP27B1 null mice with LacZreporter gene display no 25-hydroxyvitamin D(3)-1α-hydroxylase promoter activity in the skin

The hormonally active form of vitamin D(3),1α,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is synthesized in the kidney through a tightly regulated reaction catalyzed by 25-hydroxyvitamin D(3)-1α-hydroxylase (1α-hydroxylase), the product of the CYP27B1 gene. Through gene targeting in embryonic stem c...

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Главные авторы: Vanhooke, Janeen L., Prahl, Jean M., Kimmel-Jehan, Christine, Mendelsohn, Monica, Danielson, Eric W., Healy, Kevin D., DeLuca, Hector F.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1325002/
https://ncbi.nlm.nih.gov/pubmed/16371465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509734103
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