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Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2α RNA-dependent protein kinase

Phosphorylation of the α-subunit of translation eukaryotic initiation factor-2 (eIF2) leads to the inhibition of protein synthesis in response to diverse conditions of stress. Serine/threonine RNA-dependent protein kinase (PKR) is an eIF2α kinase family member induced by type I IFN and activated in...

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Bibliografiske detaljer
Main Authors: Su, Qiaozhu, Wang, Shuo, Baltzis, Dionissios, Qu, Li-Ke, Wong, Andrew Hoi-Tao, Koromilas, Antonis E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1324992/
https://ncbi.nlm.nih.gov/pubmed/16373505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508207103
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