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A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF(165)
Aptamers recognize their targets with extraordinary affinity and specificity. The aptamer-based therapeutic, Macugen, is derived from a modified 2′fluoro pyrimidine RNA inhibitor to vascular endothelial growth factor (VEGF) and is now being used to treat the wet form of age-related macular degenerat...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1323181/ https://ncbi.nlm.nih.gov/pubmed/16357200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509069102 |
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