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Evidence for an essential function of the N terminus of a small heat shock protein in vivo, independent of in vitro chaperone activity

To investigate the mechanism of small heat shock protein (sHsp) function, unbiased by current models of sHsp chaperone activity, we performed a screen for mutations of Synechocystis Hsp16.6 that reduced the ability of the protein to provide thermotolerance in vivo. Missense mutations at 17 positions...

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Detalhes bibliográficos
Main Authors: Giese, Kim C., Basha, Eman, Catague, Belmund Y., Vierling, Elizabeth
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1323161/
https://ncbi.nlm.nih.gov/pubmed/16365319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506169103
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