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A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides
MutT-related proteins, including the Escherichia coli MutT and human MutT homologue 1 (MTH1) proteins, degrade 8-oxo- 7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP) to a monophosphate, thereby preventing mutations caused by the misincorporation of 8-oxoguanine into DNA. Here, we report that hum...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1319193/ https://ncbi.nlm.nih.gov/pubmed/12717453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor838 |
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