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Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein

Werner syndrome (WS) is an autosomal recessive disease that results in premature aging. Mutations in the WS gene (WRN) result in a loss of expression of the WRN protein and predispose WS patients to accelerated aging. As a helicase and a nuclease, WRN is unique among the five human RecQ helicase fam...

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Bibliografske podrobnosti
Main Authors: Hu, Jin-Shan, Feng, Hanqiao, Zeng, Wangyong, Lin, Guang-xin, Xi, Xu Guang
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317980/
https://ncbi.nlm.nih.gov/pubmed/16339893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509380102
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