N- and C-Terminal Cooperation in Rotavirus Enterotoxin: Novel Mechanism of Modulation of the Properties of a Multifunctional Protein by a Structurally and Functionally Overlapping Conformational Domain

Rotavirus NSP4 is a multifunctional endoplasmic reticulum (ER)-resident nonstructural protein with the N terminus anchored in the ER and about 131 amino acids (aa) of the C-terminal tail (CT) oriented in the cytoplasm. Previous studies showed a peptide spanning aa 114 to 135 to induce diarrhea in ne...

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Detalhes bibliográficos
Main Authors: Jagannath, M. R., Kesavulu, M. M., Deepa, R., Sastri, P. Narayan, Kumar, S. Senthil, Suguna, K., Rao, C. Durga
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317517/
https://ncbi.nlm.nih.gov/pubmed/16352566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.1.412-425.2006
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