Herpes Simplex Virus DNA Synthesis Is Not a Decisive Regulatory Event in the Initiation of Lytic Viral Protein Expression in Neurons In Vivo during Primary Infection or Reactivation from Latency

The herpes simplex virus genome can enter a repressed transcriptional state (latency) in sensory neurons of the host nervous system. Although reduced permissiveness of the neuronal environment is widely accepted as a causal factor, the molecular pathway(s) directing and maintaining the viral genome...

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Bibliographic Details
Main Authors: Sawtell, N. M., Thompson, R. L., Haas, R. L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1317510/
https://ncbi.nlm.nih.gov/pubmed/16352529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.1.38-50.2006
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