Integrin-linked kinase is responsible for Ca(2+)-independent myosin diphosphorylation and contraction of vascular smooth muscle

Smooth muscle contraction is activated by phosphorylation at Ser-19 of LC(20) (the 20 kDa light chains of myosin II) by Ca(2+)/calmodulin-dependent MLCK (myosin light-chain kinase). Diphosphorylation of LC(20) at Ser-19 and Thr-18 is observed in smooth muscle tissues and cultured cells in response t...

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Detalhes bibliográficos
Main Authors: Wilson, David P., Sutherland, Cindy, Borman, Meredith A., Deng, Jing Ti, MacDonald, Justin A., Walsh, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316305/
https://ncbi.nlm.nih.gov/pubmed/16201970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051173
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