Mycobacterium tuberculosis NAD(+)-dependent DNA ligase is selectively inhibited by glycosylamines compared with human DNA ligase I

DNA ligases are important enzymes which catalyze the joining of nicks between adjacent bases of double-stranded DNA. NAD(+)-dependent DNA ligases (LigA) are essential in bacteria and are absent in humans. They have therefore been identified as novel, validated and attractive drug targets. Using virt...

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Hlavní autoři: Srivastava, Sandeep Kumar, Dube, Divya, Tewari, Neetu, Dwivedi, Namrata, Tripathi, Rama Pati, Ramachandran, Ravishankar
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2005
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316110/
https://ncbi.nlm.nih.gov/pubmed/16361267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki1006
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