Crystal Structure of Mycobacterium tuberculosis H37Rv AldR (Rv2779c), a Regulator of the ald Gene: DNA BINDING AND IDENTIFICATION OF SMALL MOLECULE INHIBITORS

Here we report the crystal structure of M. tuberculosis AldR (Rv2779c) showing that the N-terminal DNA-binding domains are swapped, forming a dimer, and four dimers are assembled into an octamer through crystal symmetry. The C-terminal domain is involved in oligomeric interactions that stabilize the...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Dey, Abhishek, Shree, Sonal, Pandey, Sarvesh Kumar, Tripathi, Rama Pati, Ramachandran, Ravishankar
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2016
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933250/
https://ncbi.nlm.nih.gov/pubmed/27006398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.700484
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