Unique Ligand Binding Sites on CXCR4 Probed by a Chemical Biology Approach: Implications for the Design of Selective Human Immunodeficiency Virus Type 1 Inhibitors

The chemokine receptor CXCR4 plays an important role as the receptor for the normal physiological function of stromal cell-derived factor 1α (SDF-1α) and the coreceptor for the entry of human immunodeficiency virus type 1 (HIV-1) into the cell. In a recent work (S. Tian et al., J. Virol. 79:12667-12...

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Main Authors: Choi, Won-Tak, Tian, Shaomin, Dong, Chang-Zhi, Kumar, Santosh, Liu, Dongxiang, Madani, Navid, An, Jing, Sodroski, Joseph G., Huang, Ziwei
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316031/
https://ncbi.nlm.nih.gov/pubmed/16306611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.24.15398-15404.2005
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