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Alternative Pathway of Metronidazole Activation in Trichomonas vaginalis Hydrogenosomes

Metronidazole and related 5-nitroimidazoles are the only available drugs in the treatment of human urogenital trichomoniasis caused by the protozoan parasite Trichomonas vaginalis. The drugs are activated to cytotoxic anion radicals by their reduction within the hydrogenosomes. It has been establish...

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Main Authors: Hrdý, Ivan, Cammack, Richard, Stopka, Pavel, Kulda, Jaroslav, Tachezy, Jan
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315937/
https://ncbi.nlm.nih.gov/pubmed/16304169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.5033-5036.2005
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