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Alternative Pathway of Metronidazole Activation in Trichomonas vaginalis Hydrogenosomes

Metronidazole and related 5-nitroimidazoles are the only available drugs in the treatment of human urogenital trichomoniasis caused by the protozoan parasite Trichomonas vaginalis. The drugs are activated to cytotoxic anion radicals by their reduction within the hydrogenosomes. It has been establish...

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Autores principales: Hrdý, Ivan, Cammack, Richard, Stopka, Pavel, Kulda, Jaroslav, Tachezy, Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315937/
https://ncbi.nlm.nih.gov/pubmed/16304169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.5033-5036.2005
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