Alternative Pathway of Metronidazole Activation in Trichomonas vaginalis Hydrogenosomes

Metronidazole and related 5-nitroimidazoles are the only available drugs in the treatment of human urogenital trichomoniasis caused by the protozoan parasite Trichomonas vaginalis. The drugs are activated to cytotoxic anion radicals by their reduction within the hydrogenosomes. It has been establish...

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Bibliographic Details
Main Authors: Hrdý, Ivan, Cammack, Richard, Stopka, Pavel, Kulda, Jaroslav, Tachezy, Jan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315937/
https://ncbi.nlm.nih.gov/pubmed/16304169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.5033-5036.2005
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