Discovery and Characterization of Vicriviroc (SCH 417690), a CCR5 Antagonist with Potent Activity against Human Immunodeficiency Virus Type 1

Inhibiting human immunodeficiency virus type 1 (HIV-1) infection by blocking the host cell coreceptors CCR5 and CXCR4 is an emerging strategy for antiretroviral therapy. Currently, several novel coreceptor inhibitors are being developed in the clinic, and early results have proven promising. In this...

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Detalhes bibliográficos
Main Authors: Strizki, Julie M., Tremblay, Cecile, Xu, Serena, Wojcik, Lisa, Wagner, Nicole, Gonsiorek, Waldemar, Hipkin, R. William, Chou, Chuan-Chu, Pugliese-Sivo, Catherine, Xiao, Yushi, Tagat, Jayaram R., Cox, Kathleen, Priestley, Tony, Sorota, Steve, Huang, Wei, Hirsch, Martin, Reyes, Gregory R., Baroudy, Bahige M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315929/
https://ncbi.nlm.nih.gov/pubmed/16304152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.12.4911-4919.2005
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