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A carboxy-terminal domain determines the subunit specificity of KCNQ K(+) channel assembly

Mutations in KCNQ K(+) channel genes underlie several human pathologies. KCNQ α-subunits form either homotetramers or hetero-oligomers with a restricted subset of other KCNQ α-subunits or with KCNE β-subunits. KCNQ1 assembles with KCNE β-subunits but not with other KCNQ α-subunits. By contrast, KCNQ...

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Main Authors: Schwake, Michael, Jentsch, Thomas J., Friedrich, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: 2003
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1315815/
https://ncbi.nlm.nih.gov/pubmed/12524525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.embor715
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