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Conformational Changes in HIV-1 gp41 in the Course of HIV-1 Envelope Glycoprotein-Mediated Fusion and Inactivation

HIV-1 envelope glycoprotein-mediated fusion is driven by the concerted coalescence of the HIV-1 gp41 N- and C-helical regions, which results in the formation of 6-helix bundles. These two regions are considered prime targets for peptides and antibodies that inhibit HIV-1 entry. However, the paramete...

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Bibliographic Details
Main Authors: Dimitrov, Antony S., Louis, John M., Bewley, Carole A., Clore, G. Marius, Blumenthal, Robert
Format: Artigo
Language:Inglês
Published: 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1314968/
https://ncbi.nlm.nih.gov/pubmed/16156659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi051092d
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