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Fat storage in adipocytes requires inactivation of leptin's paracrine activity: Implications for treatment of human obesity
Hyperleptinemia rapidly depletes adipocyte fat in lean rats, whereas comparable hyperleptinemia produced by adipocytes in diet-induced obesity does not, implying a leptinergic blockade in adipocytes during overnutrition. Indeed, activated STAT-3 in white adipose tissue (WAT) of normal rats was less...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1312408/ https://ncbi.nlm.nih.gov/pubmed/16326804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509001102 |
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