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Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
Topoisomerase II (Topo II) inhibitors are cell cycle–specific DNA-damaging agents and often correlate with secondary leukemia with chromosomal translocations involving the mixed-lineage leukemia/myeloid lymphoid leukemia (MLL) gene on chromosome 11 band q23 (11q23). In spite of the clinical importan...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1312016/ https://ncbi.nlm.nih.gov/pubmed/16357944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25716 |
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