Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations

Topoisomerase II (Topo II) inhibitors are cell cycle–specific DNA-damaging agents and often correlate with secondary leukemia with chromosomal translocations involving the mixed-lineage leukemia/myeloid lymphoid leukemia (MLL) gene on chromosome 11 band q23 (11q23). In spite of the clinical importan...

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Autores principales: Nakada, Shinichiro, Katsuki, Yoko, Imoto, Issei, Yokoyama, Tetsuji, Nagasawa, Masayuki, Inazawa, Johji, Mizutani, Shuki
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2006
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1312016/
https://ncbi.nlm.nih.gov/pubmed/16357944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25716
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