Nalaganje...
Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
Apolipoprotein (apo) E4, a 299-aa protein and a major risk factor for Alzheimer's disease, can be cleaved to generate C-terminal-truncated fragments that cause neurotoxicity in vitro and neurodegeneration and behavioral deficits in transgenic mice. To investigate this neurotoxicity, we expresse...
Shranjeno v:
| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2005
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1311737/ https://ncbi.nlm.nih.gov/pubmed/16344479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0508254102 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|