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The polypyrimidine tract-binding protein stimulates HIF-1α IRES-mediated translation during hypoxia
When oxygen supply is restricted, protein synthesis is rapidly abrogated owing to inhibition of global translation. However, HIF-1α protein expression can persist during hypoxia, owing to an internal ribosome entry site (IRES) in the 5′-untranslated region of its mRNA. Here, we report on the molecul...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1310900/ https://ncbi.nlm.nih.gov/pubmed/16396835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki1000 |
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