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Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease

Neuronal expression of cyclooxygenase-2 (COX-2) and cell cycle proteins is suggested to contribute to neurodegeneration during Alzheimer's disease (AD). The stimulus that induces COX-2 and cell cycle protein expression in AD is still elusive. Activated glia cells are shown to secrete substances...

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Bibliografski detalji
Glavni autori: Hoozemans, Jeroen JM, van Haastert, Elise S, Veerhuis, Robert, Arendt, Thomas, Scheper, Wiep, Eikelenboom, Piet, Rozemuller, Annemieke JM
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1308853/
https://ncbi.nlm.nih.gov/pubmed/16300681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-2-27
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