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Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α
In mammalian cells, as in Schizosaccharomyces pombe and Drosophila, HP1 proteins bind histone H3 tails methylated on lysine 9 (K9). However, whereas K9-methylated H3 histones are distributed throughout the nucleus, HP1 proteins are enriched in pericentromeric heterochromatin. This observation sugges...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2002
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1307621/ https://ncbi.nlm.nih.gov/pubmed/12231507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf194 |
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