A Mutant of Francisella tularensis Strain SCHU S4 Lacking the Ability To Express a 58-Kilodalton Protein Is Attenuated for Virulence and Is an Effective Live Vaccine

Francisella tularensis subsp. tularensis (type A) strain SCHU S4 is a prototypic strain of the pathogen that is highly virulent for humans and other mammals. Its intradermal (i.d.) 50% lethal dose (LD(50)) for mice is <10 CFU. We discovered a spontaneous mutant, designated FSC043, of SCHU S4 with...

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Bibliographic Details
Main Authors: Twine, Susan, Byström, Mona, Chen, Wangxue, Forsman, Mats, Golovliov, Igor, Johansson, Anders, Kelly, John, Lindgren, Helena, Svensson, Kerstin, Zingmark, Carl, Conlan, Wayne, Sjöstedt, Anders
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1307091/
https://ncbi.nlm.nih.gov/pubmed/16299332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.12.8345-8352.2005
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