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A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1

The Rad17-Mec3-Ddc1 complex is essential for the cellular response to genotoxic agents and is thought to be important for sensing DNA lesions. Deletion of any of the RAD17, MEC3 or DDC1 genes abolishes the G(1) and G(2) and impairs the intra-S DNA-damage checkpoints. We characterize a dominant-negat...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Giannattasio, Michele, Sommariva, Elena, Vercillo, Raffaella, Lippi-Boncambi, Filippo, Liberi, Giordano, Foiani, Marco, Plevani, Paolo, Muzi-Falconi, Marco
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130575/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12271137/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.202463999
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