A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1

The Rad17-Mec3-Ddc1 complex is essential for the cellular response to genotoxic agents and is thought to be important for sensing DNA lesions. Deletion of any of the RAD17, MEC3 or DDC1 genes abolishes the G(1) and G(2) and impairs the intra-S DNA-damage checkpoints. We characterize a dominant-negat...

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Detalhes bibliográficos
Main Authors: Giannattasio, Michele, Sommariva, Elena, Vercillo, Raffaella, Lippi-Boncambi, Filippo, Liberi, Giordano, Foiani, Marco, Plevani, Paolo, Muzi-Falconi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC130575/
https://ncbi.nlm.nih.gov/pubmed/12271137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202463999
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