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The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion

In the Chapel Hill colony of factor VIII-deficient dogs, abnormal sequence (ch8, for canine hemophilia 8, GenBank no. AF361485) follows exons 1–22 in the factor VIII transcript in place of exons 23–26. The canine hemophilia 8 locus (ch8) sequence was found in a 140-kb normal dog genomic DNA bacteria...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Lozier, Jay N., Dutra, Amalia, Pak, Evgenia, Zhou, Nan, Zheng, Zhili, Nichols, Timothy C., Bellinger, Dwight A., Read, Marjorie, Morgan, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2002
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC130574/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12242334/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.192219599
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