Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin

Duchenne muscular dystrophy is a lethal X-linked recessive disorder caused by mutations in the dystrophin gene. Delivery of functionally effective levels of dystrophin to immunocompetent, adult mdx (dystrophin-deficient) mice has been challenging because of the size of the gene, immune responses aga...

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Hauptverfasser: DelloRusso, Christiana, Scott, Jeannine M., Hartigan-O'Connor, Dennis, Salvatori, Giovanni, Barjot, Catherine, Robinson, Ann S., Crawford, Robert W., Brooks, Susan V., Chamberlain, Jeffrey S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC130572/
https://ncbi.nlm.nih.gov/pubmed/12271128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.202300099
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