טוען...

Molecular indetermination in the transition to error catastrophe: Systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity

Studies with several RNA viruses have shown that enhanced mutagenesis resulted in decreases of infectivity or virus extinction, as predicted from virus entry into error catastrophe. Here we report that lymphocytic choriomeningitis virus, the prototype arenavirus, is extremely susceptible to extincti...

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מידע ביבליוגרפי
Main Authors: Grande-Pérez, A., Sierra, S., Castro, M. G., Domingo, E., Lowenstein, P. R.
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 2002
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC130564/
https://ncbi.nlm.nih.gov/pubmed/12215495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182426999
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