The 3-Hydroxy Group and 4,5-trans Double Bond of Sphingomyelin Are Essential for Modulation of Galactosylceramide Transmembrane Asymmetry

The structural features of SPM that control the transbilayer distribution of β-GalCer in POPC vesicles were investigated by (13)C- and (31)P-NMR spectroscopy using lipid analogs that share physical similarities with GalCer or SPM. The SPM analogs included N-palmitoyl-4,5-dihydro-SPM, 3-deoxy-SPM, 1-...

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Bibliographische Detailangaben
Hauptverfasser: Malewicz, Barbara, Valiyaveettil, Jacob T., Jacob, Kochurani, Byun, Hoe-Sup, Mattjus, Peter, Baumann, Wolfgang J., Bittman, Robert, Brown, Rhoderick E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Biophysical Society 2005
Schlagworte:
Membranes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1305363/
https://ncbi.nlm.nih.gov/pubmed/15653730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.057059
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